Cajun Meatloaf

Cajun comfort food…

Looking for a comfort food recipe that has something to say in the spice department? Meet Cajun meatloaf. This Southern-inspired recipe is plenty filling with a delicious Cajun bite.

The oomph behind this meatloaf are three Southern staples: Cajun seasoning, cayenne pepper, and Tabasco sauce. It’s not overkill in terms of spiciness here – most in the family can enjoy this dish even if they aren’t normally fans of spicy food. Really, Cajun cuisine is all about the flavorful spices, not just the spiciness. Though, if you prefer some extra heat, feel free to go heavy-handed on the cayenne. An extra half teaspoon (or more to your taste) brings some extra edge for those more die-hard spicy food fans. Or try adding a touch of cayenne to the honey ketchup that tops the meatloaf. 

Cajun meatloaf

Cajun Meatloaf

3.89 from 9 votes
Prep Time 15 minutes
Cook Time 1 hour
Total Time 1 hour 15 minutes
Servings 8 servings
Calories 707 kcal


  • 2 pounds ground chuck
  • 1 pound ground pork
  • 10 cloves garlic minced
  • 5 celery ribs diced
  • 3 bell peppers diced
  • 2 yellow onions diced
  • 3 eggs
  • 1 1/2 cups breadcrumbs
  • 1 1/4 cups ketchup divided
  • 1/2 cup milk
  • 1/3 cup butter
  • 1 tablespoon Worcestershire sauce
  • 1 tablespoon honey
  • 1 tablespoon sea salt
  • 1 teaspoon cayenne pepper
  • 1 teaspoon Cajun seasoning or Creole seasoning
  • 1/3 teaspoon Tabasco sauce
  • 1 teaspoon black pepper
  • 1 teaspoon ground nutmeg


  • Preheat oven to 400 degrees Fahrenheit and prep an aluminum-foil-lined baking dish for the meatloaf.
  • In a saucepan over medium heat, melt the butter then add the bell pepper, yellow onion, celery, and garlic. Sauté the mic for 3 to 4 minutes, until the onions are translucent.
  • Add the Worcestershire sauce, Tabasco sauce, sea salt, black pepper, cayenne pepper, Cajun seasoning, and nutmeg to the mix. Stir to combine.
  • Add 1/2 cup of ketchup to the mix. Stir to combine and slightly heat (approximately 1 minute).
  • Remove the saucepan from the heat and allow the sauce to cool for 5 minutes. Once cool, add the breadcrumbs and stir until the mix forms a paste.
  • In a separate large mixing bowl, beat the eggs then add the milk. Stir well.
  • Add the ground pork and beef to the beaten eggs and knead the pork and beef to combine all ingredients.
  • Add the vegetable mix to the meat and continue kneading to combine all ingredients.
  • Transfer the meat to the foil-lined baking dish and evenly spread the meat into loaf form.
  • Combine the remaining 3/4 cup of ketchup with 1 tablespoon of honey. Stir well, then evenly spread the ketchup over the top of the meatloaf.
  • Bake the meatloaf for 35 to 40 minutes, or until the meat is thoroughly cooked.
  • Remove from the oven and allow the meatloaf to cool for 5 minutes, then remove from the baking dish, slice, and serve.


Want it spicier? Start with 1/4 to 1/2 teaspoon of cayenne extra in the meatloaf. You can also add a small amount of cayenne (a pinch or two) to the ketchup that tops the meatloaf. 


Calories: 707kcalCarbohydrates: 35gProtein: 36gFat: 45gSaturated Fat: 19gCholesterol: 204mgSodium: 1614mgPotassium: 911mgFiber: 3gSugar: 16gVitamin A: 2280IUVitamin C: 63.5mgCalcium: 129mgIron: 4.7mg
Did you make this?Mention @PepperScale or tag #PepperScale so we can see what you made!

UPDATE NOTICE: This post was updated on August 30, 2020 to include new content.
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